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Chronic Hand Eczema (CHE) is a common skin condition that affects about 1 in 10 adults. Symptoms include itch and pain, thickened or flaking skin and dryness, redness, and cracking and bleeding—all on the skin of the hands and wrists. These symptoms can persist and may return multiple times, and may even stop you from living your life the way you normally would.

The only way to truly know if you have Chronic Hand Eczema (CHE) is to see a doctor (ideally, a dermatologist), but here are some key things that make CHE different:

• appears anywhere on the hands and wrists

and

• lasts for more than 3 months

or

• returns 2 or more times in a year

Try the CHE Assessment before your doctor visit. It can help get you ready to discuss your symptoms.

There are multiple, overlapping reasons Chronic Hand Eczema (CHE) occurs, and it may be triggered by more than 1 thing.

Sensitivity to allergens and exposure to allergens like metals and rubbers can cause CHE. Exposure to irritating substances like soaps and chemicals can also cause CHE. See more triggers.

The risk can also be higher if you have been diagnosed with eczema (atopic dermatitis) on other places on the body.

ANZUPGO is the first and only FDA-approved treatment specifically designed for adults with moderate-to-severe Chronic Hand Eczema (CHE). ANZUPGO is for those whose symptoms are uncontrolled with topical steroids or for whom steroids are not advisable.

When ANZUPGO is applied to the skin, it works to block 4 signaling proteins in your body that trigger the flares seen in Chronic Hand Eczema (CHE).

These proteins are called "JAKs."

ANZUPGO is the only treatment option for CHE that works by blocking all 4 JAKs.

JAK=Janus kinase.

The effects of ANZUPGO were observed in 2 clinical studies of adults with moderate-to-severe Chronic Hand Eczema (CHE).

Learn more about skin clearance results.

Learn more about symptom relief.

Learn more about safety and side effects.

Before starting ANZUPGO, tell your healthcare provider if you:

• are being treated for an infection
• have an infection that does not go away or that keeps coming back
• have TB or have been in close contact with someone with TB
• have had shingles (herpes zoster)
• have had hepatitis B or C
• think you have an infection or have symptoms of an infection such as fever, sweating, or chills; muscle aches; cough or shortness of breath; blood in your phlegm; weight loss; warm, red, or painful skin or sores on your body; diarrhea or stomach pain; burning when you urinate or urinating more often than usual; and/or feeling very tired

• application site reactions, including pain, tingling, itching, and redness; bacterial skin infections, including finger cellulitis and nail infections; and low white blood cells

These are not all of the possible side effects of ANZUPGO. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

No, ANZUPGO is not a steroid. It is a type of medicine called a “pan-JAK inhibitor.”

JAK=Janus kinase.

Both are types of medicines that target proteins in the body called JAKs.

There are 4 JAKs: JAK1, JAK2, JAK3, and TYK2. JAK inhibitors block some JAKs.

As a pan-JAK inhibitor, ANZUPGO blocks all 4. ("Pan" means "all.")

JAK=Janus kinase; TYK2=tyrosine kinase 2.

Yes. ANZUPGO can vary in color from white to slightly brown.